Updated Clinical Information

Information on vaccines and recommendations is constantly evolving.  Please refer to the CDC website for the most recent recommendations.

Click links below to read more.

Abstracted from recommendations of the Advisory Committee on Immunization Practices (ACIP), April 2013.

Updated Recommendations for Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine (Tdap) in Pregnant Women – Includes sections on Tdap in every pregnancy, potential impact of Tdap during pregnancy, safety of repeat Tdap to pregnant women and vaccination during the third trimester.

Advisory Committee on Immunization Practices (ACIP), 2012. MMWR February 22, 2013 / 62(07);131-135.

Update on Immunization and Pregnancy: Tetanus, Diphtheria, and Pertussis Vaccination

American College of Obstetricians and Gynecologists – Committee Opinion Number 566, June 2013 (Replaces No. 521, March 2012). 

Vaccine Status Table – Status of Recently Submitted, Licensed, and Recommended Vaccines from Red Book Online.

AAP Table updated May 2013.

Pertussis Outbreak CDC Link  – Outbreak activity, trends and clinical articles.

Content Source: National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, last updated March 2013. 

Vaccine Recommendations for Health Professionals (CDC) – Updated links including ACIP recommendations, summary of recommendations, Tdap for pregnant women, healthcare personnel recommendations (.pdf), standing orders, contraindications, and ACIP Vaccines for Children (VCF) resolutions.

Content Source: National Center for Immunization and Respiratory Diseases, page last modified March 2013. 

Clinical Information on Pertussis for Health Professionals (CDC) – Updated links for outbreaks and pseudo-outbreaks, Pediarix and combined Tdap vaccine information and recommendations.

Content source: National Center for Immunization and Respiratory Diseases, page last modified March 2013.

Tdap for Pregnant Women: Information for Providers –  Source for Tdap in pregnancy and related information including: pertussis epidemiology, seriousness of pertussis for mother and infant, Tdap vaccine safety for mother and infant, breastfeeding safety after Tdap vaccination, transfer of pertussis antibodies to infant through maternal Tdap vaccination, pertussis vaccine for infant at birth, DTaP effectiveness for infant if mother vaccinated with Tdap during pregnancy, postpartum Tdap vaccination as an option, and cocooning.

Content Source: National Center for Immunization and Respiratory Diseases, page last modified February 2013.

Clinical Papers/Journal Articles (CDC) – Vaccine Recommendations and Licensures, Surveillance, Epidemiology, Outbreaks and Laboratory.

Content Source: National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, page last updated February 2013.

Cocooning and Tdap Vaccination – Featured Resources – Information from CDC, ACOG, AAP, CA Department of Public Health, TX Department of State Health Services, and Nation Association of County and City Health Officials: Model Programs.

Content Source: Immunization Action Coalition, updated February 2013.

Best Practices on the use of Polymerase Chain Reaction (PCR) for Diagnosing Pertussis – Testing, optimal timing, optimal specimen collection, and understanding and interpreting test results.

Content Source: National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, page last reviewed May 2012. 

The number needed to vaccinate to prevent infant pertussis hospitalization and death through parent cocoon immunization(Abstract) Communicable Disease Prevention and Control Services, British Columbia Centre for Disease Control (BCCDC), Vancouver; Canada.  Clin Infect Dis. 2012 Feb 1;54(3):318-27. Epub 2011 Dec 8.

Update on Immunization and Pregnancy: Tetanus, Diphtheria, and Pertussis Vaccination

American College of Obstetricians and Gynecologists – Committee Opinion Number 521, March 2012 (Replaces No. 438, August 2009). 

ACIP Votes to Expand Tdap Vaccine Recommendation – For patients 65 and older.

American Academy of Family Physicians, February 2012. 

Model for the Circle of Protection Tdap Program – Includes description of responsiveness and innovation, agency and community roles, costs and expenditures, implementation, and sustainability.

Submitted by Colorado Tri-County Health Department, 2011. 

Updated Recommendations for Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine (Tdap) in Pregnant Women and Persons Who Have or Anticipate Having Close Contact with an Infant Aged <12 Months

Advisory Committee on Immunization Practices (ACIP), 2011. MMWR October 21, 2011 / 60(41);1424-1426.

Additional Recommendations for Use of Tetanus Toxoid, Reduced-Content Diphtheria Toxoid, and Acellular Pertussis Vaccine (Tdap): Policy Statement

Pediatrics Vol. 128 No. 4 October 1, 2011 pp. 809 -812 (doi: 10.1542/peds.2011-1752). This policy is a revision of the policy in 117 (3): 965.

Updated Recommendations for Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis (Tdap) Vaccine – Timing of Tdap following Td, Adults aged 65 and older, and Undervaccinated Childred aged 7-10.

Advisory Committee on Immunization Practices (ACIP), 2010. MMWR January 14, 2011 / 60(01); 13-15. 

Pertussis Diagnostic Test Summary – Summary of diagnostic tests for pertussis.

Association of Public Health Laboratories in conjunction with the CDC (May 2010).

Prevention of Pertussis, Tetanus, and Diphtheria Among Pregnant and Postpartum Women and Their Infants – Recommendations of the Advisory Committee on Immunization Practices (ACIP).

MMRW Recommendations and Reports May 30, 2008 / 57 (04);1-47,51.

Recommendations of the Advisory Committee on Immunization Practices (ACIP) and Recommendation of ACIP, supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC), for Use of Tdap Among Health-Care Personnel

MMWR December 15, 2006 / 55(RR17);1-33.

Attitudes of US Obstetricians Toward a Combined Tetanus-Diphtheria-Acellular Pertussis Vaccine for Adults

Infect Dis Obstet Gynecol. 2006; 2006: 87040.

General Guidelines for Pertussis Case Investigation and Surveillance – Flow chart of pertussis case and contact investigation.

Dalya Güri, MD, MPH and Rebecca Martin, PhD (Originally published in 2000, amendments made in 2005 and 2006, as of Feb 2013 there are no plans for updating these guidelines).